EDEM1 reveals a quality control vesicular transport pathway out of the endoplasmic reticulum not involving the COPII exit sites

Immature and nonnative proteins are retained in the endoplasmic reticulum (ER) by the quality control machinery. Folding-incompetent glycoproteins are eventually targeted for ER-associated protein degradation (ERAD). EDEM1 (ER degradation-enhancing α-mannosidase-like protein 1), a putative mannose-b...

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Bibliographische Detailangaben
Hauptverfasser: Zuber, Christian, Cormier, James H., Guhl, Bruno, Santimaria, Roger, Hebert, Daniel N., Roth, Jürgen
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2007
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1810509/
https://ncbi.nlm.nih.gov/pubmed/17360537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700154104
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