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The Nestin progenitor lineage is the compartment of origin for pancreatic intraepithelial neoplasia

To determine the cell compartment in which initial oncogenic mutations occur in pancreatic ductal adenocarcinoma (PDAC), we generated a mouse model in which endogenous expression of mutated Kras (Kras(G12D)) was initially directed to a population of pancreatic exocrine progenitors characterized by t...

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Detalles Bibliográficos
Main Authors: Carrière, Catherine, Seeley, Elliott S., Goetze, Tobias, Longnecker, Daniel S., Korc, Murray
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1810329/
https://ncbi.nlm.nih.gov/pubmed/17360542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701117104
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