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The Nestin progenitor lineage is the compartment of origin for pancreatic intraepithelial neoplasia
To determine the cell compartment in which initial oncogenic mutations occur in pancreatic ductal adenocarcinoma (PDAC), we generated a mouse model in which endogenous expression of mutated Kras (Kras(G12D)) was initially directed to a population of pancreatic exocrine progenitors characterized by t...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1810329/ https://ncbi.nlm.nih.gov/pubmed/17360542 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701117104 |
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