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Dose-dependent cross-talk between the transforming growth factor-β and interleukin-1 signaling pathways
Some tumor cell lines secrete high concentrations of TGFβ or IL-1. Similarly high concentrations of each of these cytokines cross-activate the other pathway: TGFβ activates NFκB, and IL-1β activates Smads. The IL-1 signaling components IRAK, MyD88, TRAF6, and TAK1 are all required for cross-activati...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1810327/ https://ncbi.nlm.nih.gov/pubmed/17360530 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700118104 |
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