The C-terminus of complement regulator Factor H mediates target recognition: evidence for a compact conformation of the native protein

The complement inhibitor Factor H has three distinct binding sites for C3b and for heparin, but in solution uses specifically the most C-terminal domain, i.e. short consensus repeats (SCR) 20 for ligand interaction. Two novel monoclonal antibodies (mABs C14 and C18) that bind to the most C-terminal...

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Detalhes bibliográficos
Main Authors: Oppermann, M, Manuelian, T, Józsi, M, Brandt, E, Jokiranta, T S, Heinen, S, Meri, S, Skerka, C, Götze, O, Zipfel, P F
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2006
Assuntos:
Basic Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1809651/
https://ncbi.nlm.nih.gov/pubmed/16634809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2006.03071.x
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