Recombinant Mycobacterium bovis bacillus Calmette-Guérin (BCG) expressing mouse IL-18 augments Th1 immunity and macrophage cytotoxicity

Interleukin-18 (IL-18) has been demonstrated to synergize with BCG for induction of a T-helper-type 1 (Th1) immune response. Since successful treatment of superficial bladder cancer with BCG requires proper induction of Th1 immunity, we have developed a recombinant (r) BCG strain that functionally s...

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Библиографические подробности
Главные авторы: LUO, Y, YAMADA, H, CHEN, X, RYAN, A A, EVANOFF, D P, TRICCAS, J A, O'DONNELL, M A
Формат: Artigo
Язык:Inglês
Опубликовано: Blackwell Science Inc 2004
Предметы:
Animal Studies
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1809079/
https://ncbi.nlm.nih.gov/pubmed/15196240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2004.02522.x
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