Early deficit of lymphocytes in Wiskott–Aldrich syndrome: possible role of WASP in human lymphocyte maturation

Wiskott–Aldrich syndrome (WAS) is an X-linked platelet/immunodeficiency disease. The affected gene encodes WASP, a multidomain protein that regulates cytoskeletal assembly in blood cells. Patients have recurring infections, and their lymphocytes exhibit deficient proliferative responses in vitro. We...

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Bibliographic Details
Main Authors: PARK, J Y, KOB, M, PRODEUS, A P, ROSEN, F S, SHCHERBINA, A, REMOLD-O'DONNELL, E
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2004
Subjects:
Clinical Studies
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1809006/
https://ncbi.nlm.nih.gov/pubmed/15030520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2004.02409.x
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