Blocking lymphotoxin-β receptor activation diminishes inflammation via reduced mucosal addressin cell adhesion molecule-1 (MAdCAM-1) expression and leucocyte margination in chronic DSS-induced colitis

The lymphotoxin-β receptor (LTβR) pathway is critical for maintenance of organized lymphoid structures and is involved in the development of colitis. To investigate the mechanisms by which LTβR activation contributes to the pathology of chronic inflammation we used a soluble LTβR-Ig fusion protein a...

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Main Authors: STOPFER, P, OBERMEIER, F, DUNGER, N, FALK, W, FARKAS, S, JANOTTA, M, MÖLLER, A, MÄNNEL, D N, HEHLGANS, T
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 2004
Assuntos:
Animal Studies
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1808998/
https://ncbi.nlm.nih.gov/pubmed/15030510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2004.02402.x
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