Graves' hyperthyroidism and thyroiditis in HLA-DRB1*0301 (DR3) transgenic mice after immunization with thyrotropin receptor DNA

Familial and twin studies in Caucasians have established that the MHC class II allele HLA-DRB1*0301 (DR3) is a strong susceptibility gene in Graves’ hyperthyroid disease (GD). To determine if a DR3 transgene could help establish an animal model for GD, we expressed DR3 molecules in class II-knockout...

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Detalhes bibliográficos
Main Authors: FLYNN, J C, RAO, P V, GORA, M, ALSHARABI, G, WEI, W, GIRALDO, A A, DAVID, C S, BANGA, J P, KONG, Y M
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2004
Assuntos:
Animal Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1808907/
https://ncbi.nlm.nih.gov/pubmed/14678262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2004.02333.x
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