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Absence of Ret Signaling in Mice Causes Progressive and Late Degeneration of the Nigrostriatal System

Support of ageing neurons by endogenous neurotrophic factors such as glial cell line–derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) may determine whether the neurons resist or succumb to neurodegeneration. GDNF has been tested in clinical trials for the treatment of...

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Detalhes bibliográficos
Main Authors: Kramer, Edgar R, Aron, Liviu, Ramakers, Geert M. J, Seitz, Sabine, Zhuang, Xiaoxi, Beyer, Klaus, Smidt, Marten P, Klein, Rüdiger
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1808500/
https://ncbi.nlm.nih.gov/pubmed/17298183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0050039
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