One protein, two enzymes revisited: A structural entropy switch interconverts the two isoforms of acireductone dioxygenase

Acireductone dioxygenase (ARD) catalyzes different reactions between O(2) and 1,2-dihydroxy-3-oxo-5-(methylthio)pent-1-ene (acireductone) depending upon the metal bound in the active site. Ni(+2)–ARD cleaves acireductone to formate, CO and methylthiopropionate. If Fe(+2) is bound (ARD′), the same su...

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Hauptverfasser: Ju, Tingting, Goldsmith, Rachel Beaulieu, Chai, Sergio C., Maroney, Michael J., Pochapsky, Susan Sondej, Pochapsky, Thomas C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1808343/
https://ncbi.nlm.nih.gov/pubmed/16989860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2006.08.060
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