Troglitazone prevents mitochondrial alterations, β cell destruction, and diabetes in obese prediabetic rats

To determine whether the antidiabetic action of troglitazone (TGZ), heretofore attributed to insulin sensitization, also involves protection of β cells from lipoapoptosis, we treated prediabetic Zucker Diabetic Fatty rats with 200 mg/kg per day of TGZ. Their plasma-free fatty acids and triacylglycer...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Higa, Moritake, Zhou, Yan-Ting, Ravazzola, Mariella, Baetens, Danielle, Orci, Lelio, Unger, Roger H.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18065/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10500208/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.20.11513
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