Troglitazone prevents mitochondrial alterations, β cell destruction, and diabetes in obese prediabetic rats

To determine whether the antidiabetic action of troglitazone (TGZ), heretofore attributed to insulin sensitization, also involves protection of β cells from lipoapoptosis, we treated prediabetic Zucker Diabetic Fatty rats with 200 mg/kg per day of TGZ. Their plasma-free fatty acids and triacylglycer...

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Main Authors: Higa, Moritake, Zhou, Yan-Ting, Ravazzola, Mariella, Baetens, Danielle, Orci, Lelio, Unger, Roger H.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 1999
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC18065/
https://ncbi.nlm.nih.gov/pubmed/10500208
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