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Class I MHC molecules on hematopoietic cells can support intrathymic positive selection of T cell receptor transgenic T cells

The identity of cells that mediate positive selection of CD8(+) T cells was investigated in two T cell receptor (TCR) transgenic systems. Irradiated β(2)-microglobulin mutant mice or mice with mutations in both the K(b) and D(b) genes were repopulated with fetal liver cells from class I(+) TCR trans...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Zerrahn, Jens, Volkmann, Ariane, Coles, Mark C., Held, Werner, Lemonnier, Francois A., Raulet, David H.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1999
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18057/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10500200/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.20.11470
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