Point mutations in TOR confer Rheb-independent growth in fission yeast and nutrient-independent mammalian TOR signaling in mammalian cells

Rheb is a unique member of the Ras superfamily GTP-binding proteins. We as well as others previously have shown that Rheb is a critical component of the TSC/TOR signaling pathway. In fission yeast, Rheb is encoded by the rhb1 gene. Rhb1p is essential for growth and directly interacts with Tor2p. In...

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Main Authors: Urano, Jun, Sato, Tatsuhiro, Matsuo, Tomohiko, Otsubo, Yoko, Yamamoto, Masayuki, Tamanoi, Fuyuhiko
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2007
נושאים:
Biological Sciences
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1805553/
https://ncbi.nlm.nih.gov/pubmed/17360675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0608510104
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