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Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1γ

Brefeldin A-inhibited guanine nucleotide-exchange proteins (GEPs) BIG1 and BIG2 activate ADP-ribosylation factor (ARF) GTPases, which are required for vesicular trafficking. Both molecules contain one or more sites for binding protein kinase A, i.e., A kinase-anchoring protein (AKAP) sequences. Elev...

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書誌詳細
主要な著者: Kuroda, Fuminobu, Moss, Joel, Vaughan, Martha
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2007
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1805514/
https://ncbi.nlm.nih.gov/pubmed/17360629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611696104
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