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In vitro cytotoxicity and antibiotic activity of polymyxin B nonapeptide.

Polymyxin B nonapeptide, prepared by enzymic removal of the fatty acyl diaminobutyric acid side chain from polymyxin B, was about 100-fold less toxic to K562 cells than polymyxin B. MICs of polymyxin B nonapeptide against a test panel of bacteria were 2- to 64-fold lower than those of polymyxin B.

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Detalles Bibliográficos
Main Authors: Duwe, A K, Rupar, C A, Horsman, G B, Vas, S I
Formato: Artigo
Idioma:Inglês
Publicado: 1986
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC180550/
https://ncbi.nlm.nih.gov/pubmed/3021053
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