In vitro cytotoxicity and antibiotic activity of polymyxin B nonapeptide.

Polymyxin B nonapeptide, prepared by enzymic removal of the fatty acyl diaminobutyric acid side chain from polymyxin B, was about 100-fold less toxic to K562 cells than polymyxin B. MICs of polymyxin B nonapeptide against a test panel of bacteria were 2- to 64-fold lower than those of polymyxin B.

Dettagli Bibliografici

Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Duwe, A K, Rupar, C A, Horsman, G B, Vas, S I
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1986
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC180550/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3021053/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.30.2.340
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