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α-Lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-kinase/Akt signaling pathway

The phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway was recently shown to negatively regulate LPS-induced acute inflammatory responses. We previously observed that the metabolic thiol antioxidant α-lipoic acid (LA) inhibits LPS-induced expression of cellular adhesion molecu...

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Bibliografiske detaljer
Main Authors: Zhang, Wei-Jian, Wei, Hao, Hagen, Tory, Frei, Balz
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1805485/
https://ncbi.nlm.nih.gov/pubmed/17360480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700305104
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