ArhGAP9, a novel MAP kinase docking protein, inhibits Erk and p38 activation through WW domain binding

We have identified human ArhGAP9 as a novel MAP kinase docking protein that interacts with Erk2 and p38α through complementarily charged residues in the WW domain of ArhGAP9 and the CD domains of Erk2 and p38α. This interaction sequesters the MAP kinases in their inactive states through displacement...

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Detalhes bibliográficos
Main Authors: Ang, Boon K, Lim, Chun Y, Koh, Sharon S, Sivakumar, Neelamegam, Taib, Shahrizan, Lim, Kim B, Ahmed, Sohail, Rajagopal, Guna, Ong, Siew H
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1805438/
https://ncbi.nlm.nih.gov/pubmed/17284314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-2187-2-1
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