CDC45 and DPB11 are required for processive DNA replication and resistance to DNA topoisomerase I-mediated DNA damage

The antitumor agent camptothecin targets DNA topoisomerase I by reversibly stabilizing a covalent enzyme-DNA intermediate. The subsequent collision of DNA replication forks with these drug-enzyme-DNA complexes produces the cytotoxic DNA lesions that signal cell cycle arrest and ultimately lead to ce...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Reid, Robert J. D., Fiorani, Paola, Sugawara, Mizuno, Bjornsti, Mary-Ann
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 1999
Materias:	Biological Sciences
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18052/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10500195/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.20.11440
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