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Increased Common Fragile Site Expression, Cell Proliferation Defects, and Apoptosis following Conditional Inactivation of Mouse Hus1 in Primary Cultured Cells
Targeted disruption of the mouse Hus1 cell cycle checkpoint gene results in embryonic lethality and proliferative arrest in cultured cells. To investigate the essential functions of Hus1, we developed a system for the regulated inactivation of mouse Hus1 in primary fibroblasts. Inactivation of a lox...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Cell Biology
2007
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1805091/ https://ncbi.nlm.nih.gov/pubmed/17215515 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E06-10-0957 |
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