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Increased Common Fragile Site Expression, Cell Proliferation Defects, and Apoptosis following Conditional Inactivation of Mouse Hus1 in Primary Cultured Cells

Targeted disruption of the mouse Hus1 cell cycle checkpoint gene results in embryonic lethality and proliferative arrest in cultured cells. To investigate the essential functions of Hus1, we developed a system for the regulated inactivation of mouse Hus1 in primary fibroblasts. Inactivation of a lox...

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Sonraí Bibleagrafaíochta
Main Authors: Zhu, Min, Weiss, Robert S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Cell Biology 2007
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1805091/
https://ncbi.nlm.nih.gov/pubmed/17215515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E06-10-0957
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