RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

A RING finger-containing protein (AO7) that binds ubiquitin-conjugating enzymes (E2s) and is a substrate for E2-dependent ubiquitination was identified. Mutations of cation-coordinating residues within AO7’s RING finger abolished ubiquitination, as did chelation of zinc. Several otherwise-unrelated...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Lorick, Kevin L., Jensen, Jane P., Fang, Shengyun, Ong, Albert M., Hatakeyama, Shigetsugu, Weissman, Allan M.
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1999
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18039/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10500182/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.20.11364
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