Attenuation of PTEN increases p21 stability and cytosolic localization in kidney cancer cells: a potential mechanism of apoptosis resistance

BACKGROUND: The PTEN (Phosphatase and Tensin homolog deleted on chromosome Ten) tumor suppressor gene is frequently mutated or deleted in a wide variety of solid tumors, and these cancers are generally more aggressive and difficult to treat than those possessing wild type PTEN. While PTEN lies upstr...

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Detalhes bibliográficos
Main Authors: Lin, Pei-Yin, Fosmire, Susan P, Park, See-Hyoung, Park, Jin-Young, Baksh, Shairaz, Modiano, Jaime F, Weiss, Robert H
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1803787/
https://ncbi.nlm.nih.gov/pubmed/17300726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-6-16
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