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Antisense attenuation of p21 sensitizes kidney cancer to apoptosis in response to conventional DNA-damaging chemotherapy associated with enhancement of phospho-p53
PURPOSE: Kidney cancer is notoriously difficult to treat when metastatic due to its resistance to conventional chemotherapy. Thus, the 5-year survival rate of patients with metastatic renal cell carcinoma (RCC) is less than 10% and, novel approaches to treatment are needed. p21 is a cyclin kinase in...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2705194/ https://ncbi.nlm.nih.gov/pubmed/18499163 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.juro.2008.02.038 |
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