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Mitogen-activated protein kinase kinase activity is required for the G(2)/M transition of the cell cycle in mammalian fibroblasts

The mitogen-activated protein kinase (MAPK) cascade is required for mitogenesis in somatic mammalian cells and is activated by a wide variety of oncogenic stimuli. Specific roles for this signaling module in growth were dissected by inhibiting MAPK kinase 1 (MAPKK1) activity in highly synchronized N...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Wright, Jocelyn H., Munar, Erlynda, Jameson, Damon R., Andreassen, Paul R., Margolis, Robert L., Seger, Rony, Krebs, Edwin G.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1999
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18034/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10500177/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.20.11335
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