Antiparasitic Drug Nitazoxanide Inhibits the Pyruvate Oxidoreductases of Helicobacter pylori, Selected Anaerobic Bacteria and Parasites, and Campylobacter jejuni

Nitazoxanide (NTZ) exhibits broad-spectrum activity against anaerobic bacteria and parasites and the ulcer-causing pathogen Helicobacter pylori. Here we show that NTZ is a noncompetitive inhibitor (K(i), 2 to 10 μM) of the pyruvate:ferredoxin/flavodoxin oxidoreductases (PFORs) of Trichomonas vaginal...

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Detalhes bibliográficos
Main Authors: Hoffman, Paul S., Sisson, Gary, Croxen, Matthew A., Welch, Kevin, Harman, W. Dean, Cremades, Nunilo, Morash, Michael G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1803158/
https://ncbi.nlm.nih.gov/pubmed/17158936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01159-06
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