Synthesis of Omeprazole Analogues and Evaluation of These as Potential Inhibitors of the Multidrug Efflux Pump NorA of Staphylococcus aureus

A series of 11 pyrrolo[1,2-a]quinoxaline derivatives, 1a to 1k, sharing structural analogies with omeprazole, a eukaryotic efflux pump inhibitor (EPI) used as an antiulcer agent, was synthesized. Their inhibitory effect was evaluated using Staphylococcus aureus strain SA-1199B overexpressing NorA. B...

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Huvudupphovsmän: Vidaillac, Céline, Guillon, Jean, Arpin, Corinne, Forfar-Bares, Isabelle, Ba, Boubakar B., Grellet, Jean, Moreau, Stéphane, Caignard, Daniel-Henri, Jarry, Christian, Quentin, Claudine
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2007
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Mechanisms of Action: Physiological Effects
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1803156/
https://ncbi.nlm.nih.gov/pubmed/17101679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01306-05
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