Inhibition of Plasmodium falciparum Oocyst Production by Membrane-Permeant Cysteine Protease Inhibitor E64d

During asexual intraerythrocytic growth, Plasmodium falciparum utilizes hemoglobin obtained from the host red blood cell (RBC) as a nutrient source. Papain-like cysteine proteases, falcipains 2 and 3, have been reported to be involved in hemoglobin digestion and are targets of current antimalarial d...

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Main Authors: Eksi, S., Czesny, B., van Gemert, G.-J., Sauerwein, R. W., Eling, W., Williamson, K. C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1803139/
https://ncbi.nlm.nih.gov/pubmed/17178799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01012-06
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https://ncbi.nlm.nih.gov/pmc/articles/PMC1803139/
https://ncbi.nlm.nih.gov/pubmed/17178799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01012-06