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Evaluation of Accessory Gene Regulator (agr) Group and Function in the Proclivity towards Vancomycin Intermediate Resistance in Staphylococcus aureus

Simulated therapeutic vancomycin exposures were evaluated against agr wild-type and knockout Staphylococcus aureus groups I, II, III, and IV using an in vitro pharmacodynamic model. All agr groups developed intermediate resistance to vancomycin after subtherapeutic exposure. The free unbound fractio...

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Autors principals: Tsuji, Brian T., Rybak, Michael J., Lau, Kerry L., Sakoulas, George
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1803123/
https://ncbi.nlm.nih.gov/pubmed/17158941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00671-06
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