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Prediction of protein-folding mechanisms from free-energy landscapes derived from native structures

Guided by recent experimental results suggesting that protein-folding rates and mechanisms are determined largely by native-state topology, we develop a simple model for protein folding free-energy landscapes based on native-state structures. The configurations considered by the model contain one or...

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Autors principals: Alm, E., Baker, D.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 1999
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC18029/
https://ncbi.nlm.nih.gov/pubmed/10500172
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