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Near-native structure refinement using in vacuo energy minimization

One of the greatest shortcomings of macromolecular energy minimization and molecular dynamics techniques is that they generally do not preserve the native structure of proteins as observed by x-ray crystallography. This deformation of the native structure means that these methods are not generally u...

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Detalhes bibliográficos
Main Authors: Summa, Christopher M., Levitt, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1802011/
https://ncbi.nlm.nih.gov/pubmed/17360625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611593104
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