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Adrenomedullin gene expression differences in mice do not affect blood pressure but modulate hypertension-induced pathology in males

Adrenomedullin (AM) is a potent vasodilator peptide in plasma at picomolar levels. Polymorphisms in the human AM gene have been associated with genetic predisposition to diabetic nephropathy and proteinuria with essential hypertension, and numerous studies have demonstrated that endogenous AM plays...

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Detalhes bibliográficos
Main Authors: Caron, Kathleen, Hagaman, John, Nishikimi, Toshio, Kim, Hyung-Suk, Smithies, Oliver
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1802008/
https://ncbi.nlm.nih.gov/pubmed/17360661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611365104
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