Antiherpes effects and pharmacokinetic properties of 9-(4-hydroxybutyl) guanine and the (R) and (S) enantiomers of 9-(3,4-dihydroxybutyl)guanine.

Three acyclic guanosine analogs with similar structures, the (R) and (S) forms of 9-(3,4-dihydroxybutyl)guanine and 9-(4-hydroxybutyl)guanine, were compared for antiherpes activity in vivo and in vitro. The three guanosine analogs were viral thymidine kinase-dependent inhibitors of virus multiplicat...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Ericson, A C, Larsson, A, Aoki, F Y, Yisak, W A, Johansson, N G, Oberg, B, Datema, R
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1985
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC180147/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2990325/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.27.5.753
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