Estimates of the gene frequency of BRCA1 and its contribution to breast and ovarian cancer incidence.

The majority of multiple-case families that segregate both breast and ovarian cancer in a dominant fashion are due to mutations in the BRCA1 gene on chromosome 17q. In this paper, we have combined penetrance estimates for BRCA1 with the results of two population-based genetic epidemiological studies...

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Hlavní autoři: Ford, D, Easton, D F, Peto, J
Médium: Artigo
Jazyk:Inglês
Vydáno: 1995
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1801430/
https://ncbi.nlm.nih.gov/pubmed/8533776
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