Rapamycin is efficacious against primary effusion lymphoma (PEL) cell lines in vivo by inhibiting autocrine signaling

The antitumor potency of the mTOR inhibitor rapamycin (sirolimus) is the subject of intense investigations. Primary effusion lymphoma (PEL) appears as an AIDS-defining lymphoma and like Kaposi sarcoma has been linked to Kaposi sarcoma–associated herpesvirus (KSHV). We find that (1) rapamycin is effi...

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Autori principali: Sin, Sang-Hoon, Roy, Debasmita, Wang, Ling, Staudt, Michelle R., Fakhari, Farnaz D., Patel, Dhavalkumar D., Henry, David, Harrington, William J., Damania, Blossom A., Dittmer, Dirk P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2007
Soggetti:
Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1801055/
https://ncbi.nlm.nih.gov/pubmed/17082322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-06-028092
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