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Irofulven induces replication-dependent CHK2 activation related to p53 status
CHK2 and p53 are frequently mutated in human cancers. CHK2 is known to phosphorylate and stabilize p53. CHK2 has also been implicated in DNA repair and apoptosis induction. However, whether p53 affects CHK2 activation and whether CHK2 activation modulates chemosensitivity are unclear. In this study,...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1800887/ https://ncbi.nlm.nih.gov/pubmed/17118344 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2006.10.023 |
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