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Mechanism of pyrimethamine resistance in recent isolates of Plasmodium falciparum.

Clones of Plasmodium falciparum prepared from recent isolates of infected blood were studied to determine the molecular mechanism of naturally occurring pyrimethamine resistance. Total DNA, as well as thymidylate synthetase and dihydrofolate reductase activities, were characterized from these lines....

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Principais autores: McCutchan, T F, Welsh, J A, Dame, J B, Quakyi, I A, Graves, P M, Drake, J C, Allegra, C J
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1984
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC179988/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6393866/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.26.5.656
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