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Semimechanistic Pharmacokinetic/Pharmacodynamic Model for Assessment of Activity of Antibacterial Agents from Time-Kill Curve Experiments

Dosing of antibacterial agents is generally based on point estimates of the effect, even though bacteria exposed to antibiotics show complex kinetic behaviors. The use of the whole time course of the observed effects would be more advantageous. The aim of the present study was to develop a semimecha...

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Hlavní autoři: Nielsen, Elisabet I., Viberg, Anders, Löwdin, Elisabeth, Cars, Otto, Karlsson, Mats O., Sandström, Marie
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2007
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1797646/
https://ncbi.nlm.nih.gov/pubmed/17060524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00604-06
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