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Inhibition of protein kinase Cε prevents hepatic insulin resistance in nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease is strongly associated with hepatic insulin resistance and type 2 diabetes mellitus, but the molecular signals linking hepatic fat accumulation to hepatic insulin resistance are unknown. Three days of high-fat feeding in rats results specifically in hepatic steatosis...

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Detalhes bibliográficos
Main Authors: Samuel, Varman T., Liu, Zhen-Xiang, Wang, Amy, Beddow, Sara A., Geisler, John G., Kahn, Mario, Zhang, Xian-man, Monia, Brett P., Bhanot, Sanjay, Shulman, Gerald I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1797607/
https://ncbi.nlm.nih.gov/pubmed/17318260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30400
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