IκB Kinase Subunits α and γ Are Required for Activation of NF-κB and Induction of Apoptosis by Mammalian Reovirus

Reoviruses induce apoptosis both in cultured cells and in vivo. Apoptosis plays a major role in the pathogenesis of reovirus encephalitis and myocarditis in infected mice. Reovirus-induced apoptosis is dependent on the activation of transcription factor NF-κB and downstream cellular genes. To better...

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Main Authors: Hansberger, Mark W., Campbell, Jacquelyn A., Danthi, Pranav, Arrate, Pia, Pennington, Kevin N., Marcu, Kenneth B., Ballard, Dean W., Dermody, Terence S.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2007
Assuntos:
Virus-Cell Interactions
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1797491/
https://ncbi.nlm.nih.gov/pubmed/17121808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01860-06
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