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Human T-Cell Leukemia Virus Type 1 Tax Protein Down-Regulates Pre-T-Cell Receptor Alpha Gene Transcription in Human Immature Thymocytes
The human pre-T-cell receptor alpha (TCRα; pTα) gene encodes a polypeptide which associates with the TCRβ chain and CD3 molecules to form the pre-TCR complex. The surface expression of the pre-TCR is pTα dependent, and signaling through this complex triggers an early αβ T-cell developmental checkpoi...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1797236/ https://ncbi.nlm.nih.gov/pubmed/17050604 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00766-06 |
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