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Manipulation of cell cycle progression can counteract the apparent loss of correction frequency following oligonucleotide-directed gene repair

BACKGROUND: Single-stranded oligonucleotides (ssODN) are used routinely to direct specific base alterations within mammalian genomes that result in the restoration of a functional gene. Despite success with the technique, recent studies have revealed that following repair events, correction frequenc...

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Hlavní autoři: Engstrom, Julia U, Kmiec, Eric B
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2007
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1797188/
https://ncbi.nlm.nih.gov/pubmed/17284323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-8-9
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