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Selective defect of in vivo glycolysis in early Huntington's disease striatum

Activity of complexes II, III, and IV of the mitochondrial electron transport system (ETS) is reduced in postmortem Huntington's disease (HD) striatum, suggesting that reduced cerebral oxidative phosphorylation may be important in the pathogenesis of neuronal death. We investigated mitochondria...

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Detalhes bibliográficos
Main Authors: Powers, William J., Videen, Tom O., Markham, Joanne, McGee-Minnich, Lori, Antenor-Dorsey, JoAnn V., Hershey, Tamara, Perlmutter, Joel S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1797149/
https://ncbi.nlm.nih.gov/pubmed/17299049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609833104
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