When loss is gain: reduced presenilin proteolytic function leads to increased Aβ42/Aβ40. Talking Point on the role of presenilin mutations in Alzheimer disease

Lignende værker

• Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease
  af: De Strooper, Bart
  Udgivet: (2007)
• Alzheimer Presenilin-1 Mutations Dramatically Reduce Trimming of Long Amyloid β-Peptides (Aβ) by γ-Secretase to Increase 42-to-40-Residue Aβ
  af: Fernandez, Marty A., et al.
  Udgivet: (2014)
• Putting presenilins centre stage. Introduction to the Talking Point on the role of presenilin mutations in Alzheimer disease
  af: Hardy, John
  Udgivet: (2007)
• Interrelationship between Changes in the Amyloid β 42/40 Ratio and Presenilin 1 Conformation
  af: Zoltowska, Katarzyna Marta, et al.
  Udgivet: (2016)
• Cross-seeding between Aβ40 and Aβ42 in Alzheimer’s disease
  af: Tran, Joyce, et al.
  Udgivet: (2016)