Hypotension, lipodystrophy, and insulin resistance in generalized PPARγ-deficient mice rescued from embryonic lethality

We rescued the embryonic lethality of global PPARγ knockout by breeding Mox2-Cre (MORE) mice with floxed PPARγ mice to inactivate PPARγ in the embryo but not in trophoblasts and created a generalized PPARγ knockout mouse model, MORE-PPARγ knockout (MORE-PGKO) mice. PPARγ inactivation caused severe l...

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Detalhes bibliográficos
Main Authors: Duan, Sheng Zhong, Ivashchenko, Christine Y., Whitesall, Steven E., D’Alecy, Louis G., Duquaine, Damon C., Brosius, Frank C., Gonzalez, Frank J., Vinson, Charles, Pierre, Melissa A., Milstone, David S., Mortensen, Richard M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1794117/
https://ncbi.nlm.nih.gov/pubmed/17304352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI28859
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