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Asymmetric deceleration of ClpB or Hsp104 ATPase activity unleashes protein-remodeling activity

Two members of the AAA+ superfamily, ClpB and Hsp104, collaborate with Hsp70 and Hsp40 to rescue aggregated proteins. However, the mechanisms that elicit and underlie their protein-remodeling activities remain unclear. We report that for both Hsp104 and ClpB, mixtures of ATP and ATPγS unexpectedly u...

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Detalhes bibliográficos
Main Authors: Doyle, Shannon M., Shorter, James, Zolkiewski, Michal, Hoskins, Joel R., Lindquist, Susan, Wickner, Sue
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1793998/
https://ncbi.nlm.nih.gov/pubmed/17259993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb1198
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