Distinct human NUMB isoforms regulate differentiation vs. proliferation in the neuronal lineage

Neuronal cell fate decisions are directed in Drosophila by NUMB, a signaling adapter protein with two protein–protein interaction domains: a phosphotyrosine-binding domain and a proline-rich region (PRR) that functions as an SH3-binding domain. Here we show that there are at least four human NUMB is...

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Autors principals: Verdi, Joseph M., Bashirullah, Arash, Goldhawk, Donna E., Kubu, Chris J., Jamali, Mina, Meakin, Susan O., Lipshitz, Howard D.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 1999
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC17913/
https://ncbi.nlm.nih.gov/pubmed/10468633
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