Serum choline activates mutant acetylcholine receptors that cause slow channel congenital myasthenic syndromes

We have found that mutant acetylcholine receptor channels (AChRs) that cause slow-channel congenital myasthenic syndromes are activated by serum and that the high frequency of openings in serum is reduced by treatment with choline oxidase. Thus, slow-channel congenital myasthenic syndrome AChRs at t...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Zhou, Ming, Engel, Andrew G., Auerbach, Anthony
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1999
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17912/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10468632/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.18.10466
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