Genetic alteration of phospholipase C β3 expression modulates behavioral and cellular responses to μ opioids

Morphine and other μ opioids regulate a number of intracellular signaling pathways, including the one mediated by phospholipase C (PLC). By studying PLC β3-deficient mice, we have established a strong link between PLC and μ opioid-mediated responses at both the behavioral and cellular levels. Mice l...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Xie, Wei, Samoriski, Gary M., McLaughlin, Jay P., Romoser, Valerie A., Smrcka, Alan, Hinkle, Patricia M., Bidlack, Jean M., Gross, Robert A., Jiang, Huiping, Wu, Dianqing
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1999
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17897/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10468617/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.18.10385
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